Selective Androgen Receptor Modulators - A Review of Potential Uses, Benefits, Side effects and Limitations

Introduction: Selective Androgen Receptor Modulators (SARMs) are a group of chemical compounds capable of selectively activating androgen receptors (ARs) in the body. These substances can play a significant role in a new therapeutic approach in various fields of medicine, limiting the side effects associated with traditional anabolic steroids. In this article, we will focus on an overview of the current scientific knowledge on SARMs, their mechanisms of action, potential therapeutic applications, risks and challenges related to their use.  Aim of the study: The primary aim of this study was to to present potential use of selective androgen receptor modulators in sport and treatment focusing on its benefits and limitations as well as side effects aspects.  State of Knowledge:  SARMs in research show therapeutic benefits in the treatment of diseases such as osteoporosis, benign prostatic hyperplasia, muscle diseases and some types of cancer. Some studies suggest that few SARMs may be hepatotoxic. Most research on SARMs has been short-term, so the long-term effects of their use remain poorly understood.  Conclusion: The popularity of SARMs is constantly growing, and research on their use in medicine and sports provides more and more new ways to use them. Despite promising results, these compounds still pose many scientific challenges and raise legitimate concerns about their long-term effects on human health.

Do emotions organize or disorganize action?

INTRODUCTION  Emotions companions us in our everyday life and are still difficult to define. Among many functions, such as inducing physiological changes, availability to specific behaviors, the organizing or disorganizing influence of emotions is also distinguished.  OBJECTIVE  The aim of the article is to show the theory of emotions and answer the question whether they organize our actions or, on the contrary, promote disorganization.  STATE OF THE ART. DESCRIPTION  Among the many functions attributed to emotions are that they can direct our actions towards a given goal and sustain it, or vice versa. Emotion is, among other things, an expression of the action of instincts, it mobilizes the body, organizes action and performs an energizing function. Nowadays, attention is paid to the mobilizing aspects of emotions - weak or moderate emotions organize our functioning. Only a strong emotional state ceases to motivate, makes our actions disoriented. On the other hand, it is necessary to distinguish between emotional states and motivation. Watson shows emotions as a disorder of homeostasis along with numerous disorders of mental regulation. Clore, Clark, and Watson argue that dysfunctional are persistent, troublesome states that may be manifestations of affective or temperamental disorders rather than transient emotions. Speaking of emotion and its impact on action, it is worth mentioning and stopping at the issue of inhibition and expressing emotional states.    CONCLUSION  It is not possible to unequivocally determine that emotions either organize or disorganize our behavior, because a lot depends on the intensity of the experienced emotion and its directio